tremor, chill, increased blood-pressure and glycosuria. This patient was also pilocarpin-sensitive. Atropin had no therapeutic effect on the attack. Patients with exophthalmic goiter follow the clinical classification described in the outline, and a very interesting fact was noted in these cases. The region most affected, the eye, heart, etc., was more sensitive pharmacodynamically than were others not so impli¬ cated. When tachycardia was marked, epinephrin caused greater relative increase of

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... he tachycardia than it did on the blood-pressure or tremor when these were not so marked. One case showed 2 per cent, eosinophilia, after pilocarpin ; this increased to 5 per cent.