Is Regulation of Heme Catabolism Associated with Inflammation? Suggestions from Analysis of cis-Acting Elements in the Heme Oxygenase-1 Gene

羽鳥 勇太, 井上 幸江, Hatori Yuta, Inouye Sachiye, Akagi Reiko
Cellular heme catabolism is essential for multiple physiologic processes such as iron recycling, antioxidant defense, control of inflammation, and primarily depends on the activity of heme oxygenase-1 (HO-1). Although induction of HO-1 by various stimuli has been known, the underlying mechanism is not clear. In this study, we performed in silico search for cisacting elements present within 5' flanking region of HO-1 gene. In addition to known hemeand heat-operated elements, the analysis
more » ... ted binding sites for inflammation-related transcription factors including NF-κB, PPARγ, and EOMES. These sites were specifically present in mammalian and avian HO-1 genes and the most frequently found in human sequence. Collectively, the analysis indicates that HO-1 gene is under the control of multiple signaling nodes, illustrating how HO-1 activity is optimally tuned in response to various physical and inflammatory stimuli keywords:heme oxygenase-1, inflammation, heat shock, stress response
doi:10.24613/00000044 fatcat:fybhixd5gzhe7cdxfmpvu6oxqa