Cellular heme catabolism is essential for multiple physiologic processes such as iron recycling, antioxidant defense, control of inflammation, and primarily depends on the activity of heme oxygenase-1 (HO-1). Although induction of HO-1 by various stimuli has been known, the underlying mechanism is not clear. In this study, we performed in silico search for cisacting elements present within 5' flanking region of HO-1 gene. In addition to known hemeand heat-operated elements, the analysis

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... ted binding sites for inflammation-related transcription factors including NF-κB, PPARγ, and EOMES. These sites were specifically present in mammalian and avian HO-1 genes and the most frequently found in human sequence. Collectively, the analysis indicates that HO-1 gene is under the control of multiple signaling nodes, illustrating how HO-1 activity is optimally tuned in response to various physical and inflammatory stimuli keywords:heme oxygenase-1, inflammation, heat shock, stress response