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Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia
Molecular human reproduction
Pre-eclampsia, a common complication of first pregnancies, is thought to result from a poorly perfused placenta and may reflect an abnormal maternal immune reaction to the hemiallogenic fetus. Human leukocyte antigen (HLA)-G, a major histocompatibility tissue-specific antigen expressed in extravillous trophoblast cells (fetal-derived), may protect trophoblasts from maternal-fetal immune intolerance and allow these cells to invade the uterus. Through RNA in-situ hybridization analysis, wedoi:10.1093/molehr/6.1.88 pmid:10611266 fatcat:5libsdngvrcqjbvrl3sdotlbpu