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Analysis of Signalling Pathways Using Continuous Time Markov Chains
[chapter]
2006
Lecture Notes in Computer Science
We describe a quantitative modelling and analysis approach for signal transduction networks. We illustrate the approach with an example, the RKIP inhibited ERK pathway [CSK + 03]. Our models are high level descriptions of continuous time Markov chains: proteins are modelled by synchronous processes and reactions by transitions. Concentrations are modelled by discrete, abstract quantities. The main advantage of our approach is that using a (continuous time) stochastic logic and the PRISM model
doi:10.1007/11880646_3
fatcat:rd2ur64kmncqhano327w2yhag4