Organic wastes for agricultural use represent a real agronomic interest but also a risk for public and animal health. Actinomycetes present a potential source of bioactive compounds with multiple applications. Among the 88 isolates of actinomycetes obtained from different samples, we selected a strain identified, thanks to macroand microscopic characters, as Streptomyces sp. SCM21. This strain showed these potentialities to produce antibacterial metabolites against the pathogenic bacteria

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... (S. aureus, B. cereus and S. enteritidis) when cultivated in liquid and solid fermentation. Solid-state fermentation was conducted using sewage sludge as substrate. This is the first time that sewage sludge has been used to produce antibacterial metabolites by a strain of actinomycetes in solid-state fermentation. In addition, solid-state fermentation moistened with distilled water gave better antibacterial activity with good sporulation of Streptomyces sp. CSM2 1 . Thus, the product of solidstate fermentation can be used in the management of contaminated waste to control pathogenic bacteria