Enhanced apoptosis by inhibition of cisplatin-induced autophagy in human bladder cancer cells

Thomas I-Sheng Hwang, Te-Fu Tsai, Shan-Che Yang, Hung-En Chen, Yi-Chia Lin, Kuang-Yu Chou, Ji-Fan Lin
2016 Urological Science  
Conclusion: High HK2 expression in bladder cancers induced oversecretion of lactate, which was associated with metastatic behaviors through the cancer stem cell formation, EMT promotion and nuclear translocation of phosphorylated NF-kB and Twist1. HK2 may be a novel oncoprotein and play as target for bladder cancer therapy.
doi:10.1016/j.urols.2016.05.063 fatcat:re75vyjarzdknjf4m2qhwo5ezm