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Control of fear extinction by hypothalamic melanin-concentrating hormone–expressing neurons
Proceedings of the National Academy of Sciences of the United States of America
Learning to fear danger is essential for survival. However, overactive, relapsing fear behavior in the absence of danger is a hallmark of disabling anxiety disorders that affect millions of people. Its suppression is thus of great interest, but the necessary brain components remain incompletely identified. We studied fear suppression through a procedure in which, after acquiring fear of aversive events (fear learning), subjects were exposed to fear-eliciting cues without aversive events (safetydoi:10.1073/pnas.2007993117 pmid:32848057 fatcat:v4wxgx4uszbhra6o4ozfyspp2i