A Systematic Review of Computational Drug Discovery, Development, and Repurposing for Ebola Virus Disease Treatment

James Schuler, Matthew Hudson, Diane Schwartz, Ram Samudrala
2017 Molecules  
Ebola virus disease (EVD) is a deadly global public health threat, with no currently approved treatments. Traditional drug discovery and development is too expensive and inefficient to react quickly to the threat. We review published research studies that utilize computational approaches to find or develop drugs that target the Ebola virus and synthesize its results. A variety of hypothesized and/or novel treatments are reported to have potential anti-Ebola activity. Approaches that utilize
more » ... i-targeting/polypharmacology have the most promise in treating EVD.
doi:10.3390/molecules22101777 pmid:29053626 fatcat:vrr6fgmeb5d6dgity3upj66ehu