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AbstractRecent genome-wide chromosome conformation capture assays such as Hi-C and HiChIP have vastly expanded the resolution and throughput with which we can study 3D genomic architecture and function. Here, we present HiC-DC+, a software tool for Hi-C/HiChIP interaction calling and differential analysis using an efficient implementation of the HiC-DC statistical framework. HiC-DC+ integrates with popular preprocessing and visualization tools and includes topologically associating domain (TAD)doi:10.1038/s41467-021-23749-x pmid:34099725 pmcid:PMC8184932 fatcat:luifzry3kbc6nnd6q64wn747ei