Furanolabdane Diterpene Glycosides from Eremostachys Laciniata

Abbas Delazar, Masoud Modarresi, Hossein Nazemiyeh, Fatemeh Fathi-Azad, Lutfun Nahar, Satyajit D. Sarker
2008 Natural Product Communications  
and objectives: The rhizomes of Eremostachys azerbaijanica Rech. f., as an indigenous plant in East Azerbaijan province of Iran, were studied for isolation and identification of possible phytoconstituents. Methods: The air-dried and ground rhizomes were extracted with n-hexane, dichloromethane (DCM) and methanol (MeOH) using a Soxhlet apparatus. The 10%, 20% and 80% MeOH in water C18 cartridge solid phase extraction products )Sep-Pak fractions( of the MeOH extract were subjected to preparative
more » ... eversed-phase high performance liquid chromatography (RP-HPLC) and the isolated pure compounds were identified by one-dimensional nuclear magnetic resonance (1D -NMR) spectroscopic technique. Results: The spectroscopic data of the compounds were compared with the respective published data and the obtained results showed the presence of four pure components, 6 -Hydroxy loganin (1), Shanzhiside methyl ester (2), Eremostachiin (β-Dglucopyranosyl-(1→2)-β-D-glucopyranosyl ester of phlomisoic acid) (3) and Phlomisoside II (4), with iridoid and furano labdane-type diterpene glycoside structures. Conclusion: The occurrence of these types of chemical structures might be a confirmation to close relation and similar pharmacological and biological activities between Eremostachys and Phlomis genera.
doi:10.1177/1934578x0800300609 fatcat:idk5o7z3a5gabptdditw4szw2q