The role of long-range interactions in defining the secondary structure of proteins is overestimated

András Fiser, Zsuzsanna Dosztányi, István Simon
1997 Bioinformatics  
Motivation: Secondary structure predictions based on the properties of individual residues, and sometimes on local interactions, usually fail to exceed 65% efficiency. Therefore, non-local, long-range interactions seem to be a significant cause of this limitation. Results: In this paper, we apply approaches to localize highly interacting residues and clusters of residues involved in multiple non-local interactions, and test various secondary structure predictions on this separate subset to
more » ... s the effect of long-range interactions on the prediction efficiencies. It was found that only a marginal part of the failure of secondary structure predictions results from the presence of long-range interactions. Alternative possibilities are also discussed. Contact:
doi:10.1093/bioinformatics/13.3.297 fatcat:xtwip4evdvgixcx7anir27kypi