Persistence of Cajal-Retzius cells in the adult human cerebral cortex. An immunohistochemical study

R Martín, A Gutiérrez, A Peñafiel, M Marín-Padilla, A de la Calle
1999 Histology and Histopathology  
The presence of Cajal-Retzius cells in the adult human prefrontal and visual cortices has been demonstrated with calcium binding protein immunocytochemistry and NADPH-diaphorase histochemistry. These cells expressed parvalbumin, calbindin and calretinin calcium binding proteins and displayed NADPH-diaphorase enzyme activity. The three basic morphological profiles-horizontal, pyriform and multipolar-were observed. The morphologies of labelled cells resembled those of neurons observed in Golgi
more » ... dies of the human cerebral cortex. The presence of calcium binding proteins and NADPH-diaphorase in these cells suggests a possible inhibitory role as GABAergic neurons. The persistence of Cajal-Retzius cells in the adult cerebral cortex supports the idea that they undergo developmental dilution rather than postnatal degeneration.
doi:10.14670/hh-14.487 pmid:10212810 fatcat:3td6aqwd5rdwto5modnhg2vj7m