T. V. Berestova, L. A. Nizametdinova, K. N. Nosenko, E. M. Khamitov, A. G. Mustafin
2018 Vestnik Bashkirskogo universiteta  
Методом ИК-спектроскопии многократного нарушенного полного отражения и квантовохимическим моделированием изучены бис-и разнолигандные комплексы Cu(II) с L-цистином. Проведено сравнение расчетных и экспериментальных характеристических полос поглощения полученных комплексов в области валентных колебаний карбонильной группы и аминогруппы в средневолновой области ИК-спектра. Установлено, что комплексообразование Cu(II) с L-цистином проходит по бис-глициновому типу. Ключевые слова: бис-и
more » ... : бис-и разнолигандные комплексы Cu(II), L-цистин, глицин, DL-валин, ИК-спектроскопия, квантовохимическое моделирование. Поступила в редакцию 03.07.2018 г. It is known that oxidation-reduction processes of thiols, proceeding with the formation of disulfide bonds 2R-SN ↔ R-SS-R, play an important role in biological systems. Therefore, the identification of factors and key intermediates that affect the influence of the equilibrium in these processes is an important and relevant task. Thus, the redox reaction 2R-SН -2е + Ох ↔ R-SS-R +2Н + + Р (Ox-oxidizing agent, P-product of recovery) occurs in the organism with various endogenous oxidizing agents. This reaction is important for understanding the processes of intracellular signaling and oxidative modification of sulfurcontaining proteins. It is known that the of catalytic function in the considered reaction can be carried out by Cu(II) compounds due to the redox pair Cu(I)/Cu(II) in this reaction. Complexes of Cu(II) with L-сystine are also of great interest for the study of the influence of the ligand environment of the Cu(II) ion and of its functional activity in biological systems. The authors of the article studied bis-and mixed ligand complexes of Cu(II) with Lcystine by the methods of ATR-FTIR and quantum-chemical modeling. The calculated and experimental characteristic absorption bands located in the stretching vibrations region of the carbonyl group and the amino group in the IR spectra were compared. It was found that the complexation of Cu(II) with L-cystine related to bis-glycine type of reactions.
doi:10.33184/bulletin-bsu-2018.4.15 fatcat:ugjstxea7vf5fhugw7ojvzt5pm