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Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity
2016
PLoS ONE
In canonical Wnt signaling, the protein levels of the key signaling mediator β-catenin are under tight regulation by the multimeric destruction complex that mediates proteasomal degradation of β-catenin. In colorectal cancer, destruction complex activity is often compromised due to mutations in the multifunctional scaffolding protein Adenomatous Polyposis Coli (APC), leading to a stabilization of β-catenin. Recently, tankyrase inhibitors (TNKSi), a novel class of small molecule inhibitors, were
doi:10.1371/journal.pone.0160507
pmid:27482906
pmcid:PMC4970726
fatcat:hbvzv5zarjfzflcss4wbg5xccy