Encephalopathy with Staphylococcal Endocarditis: Multiple Neuropathological Findings

S.G. Weeks, C.J. Doig, C. Silva, R.N. Auer, C. Power, M.J. Gill
2001 Canadian Journal of Neurological Sciences  
Background:Infective endocarditis is associated with serious neurological sequelae.Objective:Here, we report a patient with Staphylococcus aureus endocarditis, secondary to congenital heart disease, with subacute onset of multiple neurological complications.Results:Despite prompt antibiotic treatment with rapid sterilization of blood cultures, the patient died with brain herniation within 96 hours of admission. Neuropathological examination showed intraparenchymal hemorrhages, mycotic
more » ... micro-abscesses and septic arteritis with accompanying infarction. Immunocytochemical studies revealed enhanced CD45 and GFAP immunoreactivity, together with adenosine A1 receptor detection on macrophages and microglia.Conclusion:Infective endocarditis is associated with multiple neuropathological lesions, which may contribute to its poor clinical outcome and activation of cells of monocyte-microglial lineage throughout the brain.
doi:10.1017/s0317167100001438 fatcat:2s7hhwwm7jh53ndie7xeiiygk4