Simulation has been a fundamental tool to prototype, hypothesize, and evaluate new ideas to continue improving system performance. However, increasing levels of processor parallelism and heterogeneity have introduced additional constraints when evaluating new designs. The work embodied in this dissertation explores how to leverage novel ideas in simulator partitioning to improve simulator speed and flexibility for simulating these new types of systems. The contribution of this work includes the

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... introduction of optimistic partitioned simulation to improve parallelization, and the introduction of warped partitioned simulation for improved flexibility. These ideas are refined and demonstrated through the use of prototypes to demonstrate their benefits compared to state-of-the-art approaches. By leveraging partitioning in a structured manner, it is possible to design simulators that better address the open challenges of parallel and heterogeneous systems design.