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Subcellular Localization of Epstein–Barr Virus BLLF2 and Its Underlying Mechanisms
2021
Frontiers in Microbiology
Epstein–Barr virus (EBV), the pathogen of several human malignancies, encodes many proteins required to be transported into the nucleus for viral DNA reproduction and nucleocapsids assembly in the lytic replication cycle. Here, fluorescence microscope, mutation analysis, interspecies heterokaryon assays, co-immunoprecipitation assay, RNA interference, and Western blot were performed to explore the nuclear import mechanism of EBV encoded BLLF2 protein. BLLF2 was shown to be a nucleocytoplasmic
doi:10.3389/fmicb.2021.672192
fatcat:aq6xqvikmjebta6737eesblxpe