A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf
.
Aluminum induced oxidative mitochondrial DNA release mediated by HIF-1α-related pathway to activate NLRP3 inflammasome in astrocytes
[post]
2022
unpublished
Aluminum compounds are widely distributed in nature and applied frequently in daily life, which are considered as environmental pathogenic factor of neurodegenerative diseases. Previous studies have suggested that aluminum can cause neuroinflammation, but whether astrocytes could play an important role is still obscure. Here, the rat model of subchronic aluminum exposure was established by drinking water containing AlCl3 for 12 w. Primary astrocytes were isolated and treated with AlCl3. YC-1
doi:10.21203/rs.3.rs-1673190/v1
fatcat:4rof7ihrczdkhhtil6i6tpuegm