Acanthosis nigricans in obese Chinese children
Hong Kong Medical Journal
Objectives: To investigate the demographic characteristics and insulin resistance in local overweight/obese Chinese children with and without acanthosis nigricans, and the associations of acanthosis nigricans with insulin resistance and other cardiometabolic co-morbidities. Design: Case series with cross-sectional analyses. Setting: A regional hospital in Hong Kong. Main outcome measures: The demographics, anthropometric data, acanthosis nigricans status, and biochemical results were analysed.
... lts were analysed. Results: A total of 543 overweight/obese children were studied with 64% being boys and 29% had insulin resistance. Adolescents aged 12 to 18 years, compared with children aged 5 to 11 years, were more likely to have acanthosis nigricans (63% vs 47%; P<0.001) and insulin resistance (37% vs 25%; P=0.005). Compared with overweight children, those who were obese were more likely to have the two conditions: acanthosis nigricans (59% vs 44%; P=0.005) and insulin resistance (35% vs 19%; P=0.001). Compared with those without acanthosis nigricans, those with the condition had significantly higher mean values for systolic blood pressures Acanthosis nigricans in obese Chinese children New knowledge added by this study • Hong Kong Chinese children with acanthosis nigricans were more likely to have insulin resistance, hypertension, fatty livers, and abnormal glucose homeostasis. Implications for clinical practice or policy • In children, acanthosis nigricans is an important clinical sign warranting early attention and evaluation.