Immunoreactive VIP and Substance P Levels in Human Adenoidal and Tonsilar Tissues
アデノイド・口蓋扁桃組織中Substance PおよびVIP濃度

Shigemi Yoshihara, Hidemi Asai, Toshio Abe, Norimasa Fukuda, Kouichi Ami, Tohju Ichimura
1991 Pediatric Otorhinolaryngology Japan  
Using specific radioimmunoassay we tried to determine whether any neuropeptides, VIP or SP, may exist in adenoidal and palatine tonsillar tissues in human. Adenoidal tissues of 8 cases (hypertrophic adenoids of patients aged 5 to 13 years, 4 males and 4 females) and palatine tonsillar tissues of 3 cases (hypertrophic tonsils of 3 cases aged 8 to 13 years, 1 male and 2 females)were obtained by operations. In the adenoids VIP values averaged 4492±1781 pg/g w.w.t. and SP, in contrast,20±6pg/g
more » ... .. In the palatine tonsils VIP values averaged 3010±925pg/g w.w.t. and SP, in contrast, 13±5pg/g w.w.t.. Thus, the average of VIP level was 100-times higher than that of SP. Since VIP likely controls proliferation of lymphocyte subpopulation and SP causes so-called neurogenic inflammation, these findings suggest that neuropeptides, VIP and SP, are closely involved in the pathophysiology of inflammatory diseases in adenoids and palatine tonsils.
doi:10.11374/shonijibi1980.12.1_54 fatcat:hch6eiirhjcatndgmxxpfagsua