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Mutational Analysis Reveals Distinct Features of the Nox4-p22phoxComplex
2008
Journal of Biological Chemistry
The integral membrane protein p22 phox forms a heterodimeric enzyme complex with NADPH oxidases (Noxs) and is required for their catalytic activity. Nox4, a Nox linked to cardiovascular disease, angiogenesis, and insulin signaling, is unique in its ability to produce hydrogen peroxide constitutively. To date, p22 phox constitutes the only identified regulatory component for Nox4 function. To delineate structural elements in p22 phox essential for formation and localization of the Nox4-p22 phox
doi:10.1074/jbc.m804200200
pmid:18849343
pmcid:PMC2596391
fatcat:sa7vmcywpzbhhfszjyozasbfuu