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ATAD2 controls chromatin-bound HIRA turnover
2021
Life Science Alliance
Taking advantage of the evolutionary conserved nature of ATAD2, we report here a series of parallel functional studies in human, mouse, and Schizosaccharomyces pombe to investigate ATAD2's conserved functions. In S. pombe, the deletion of ATAD2 ortholog, abo1, leads to a dramatic decrease in cell growth, with the appearance of suppressor clones recovering normal growth. The identification of the corresponding suppressor mutations revealed a strong genetic interaction between Abo1 and the
doi:10.26508/lsa.202101151
pmid:34580178
pmcid:PMC8500222
fatcat:i3qwbcptancjnhfww4qnqi5q2m