In this present study attempt was made to prepare the floating microspheres of Omeprazol which will help in releasing the proton pump inhibitor drugs in stomach. So that they can be absorbed in stomach for a longer period of time and show better bioavailability. The IR spectrum of pure drug and drug mixture indicated that there was no interaction between polymers and drug. The DSC also revealed that there was no interaction between polymers and drug. The shape of microspheres was almost

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... l and smooth as indicated by SEM. Encapsulation efficiency was in the range of 66.23±0.115 to 88.53±0.578%. As the polymer concentration increases, the encapsulation efficiency also increases. In vitro buoyancy studies of the prepared microspheres was in the range of 70.9 to 79.1%.Omeprazole release from microspheres was slow and extended period of time due to increase in polymer concentration. The release mechanisms for all the formulation followed by non-fickian diffusion mechanism. The drug release from formulation OMP6 showed 87.26% for a long period of 12hrs and also observed that increase in Eudragit S100 concentration the drug release was decreased. The release mechanisms for all the formulation followed by non-fickian diffusion mechanism.