Incidence of DVT in post-operative lower limb trauma patients and the role of rivaroxaban in prevention of DVT

Dr. Laxmikanta Debata, Dr Alok Gadkari, Dr Sanjay N Patil
2020 International Journal of Orthopaedics Sciences  
Deep vein thrombosis (DVT) is a common cause of morbidity and mortality after Orthopedic surgery. Some recent studies report an increasing incidence of VTE in the Indian subcontinent. Rivaroxaban was found to be safe and effective for thromboprophylaxis after major Orthopedic surgery across a wide range of doses. Aim: To study incidence of DVT in lower limb trauma patients and the efficacy and safety of oral rivaroxaban, 10 mg once daily, administered postoperatively, for the prevention of
more » ... prevention of venous thromboembolism. Material and Methods: A total of 200 patients selected by simple random sampling with lower limb trauma admitted for surgery in the hospital were included in the study. The patients were randomized into two groups of 100 patients each. RE was given oral Rivaroxaban, 10 mg once daily for the prevention of venous thromboembolism and Group E, control group, for which no prophylaxis was given. Results: Incidence of DVT was 3% in Group RE and 6% in group E. There was statistical significant difference when two groups were compared statistically. Incidence was 7% in males and 2% in females. The mean duration of treatment in patients in Group RE was 26.32± 13.21 days and in Group E was 16.32 ±4.21 days. The adverse event of bleeding in patients of Group RE was 3% and in Group E was 2% with no statistically difference. Conclusion: DVT in Indian patients with lower limb trauma is a fair problem and hence pharmacological prophylaxis should be used only for all patients with risk factors. Rivaroxaban offers a simple, approach to the short-term treatment of DVT that may improve the benefit-risk profile of anticoagulation.
doi:10.22271/ortho.2020.v6.i2d.2041 fatcat:u6zvsrrnmzhfnoyn6gllxabney