The aim of this study was to investigate thyroid hormones (T 3 , T 4) and its regulatory hormone (TSH) levels in obese women with sedentary life style. The studied population consists of 180 female subjects of age group 20-45 years. The study was carried out on female population of Allama Iqbal Town, Samanabad, and Lahore College for Women University, Lahore. The subjects were divided into three categories on the basis of body mass index (BMI): normal weight subjects (n=60) overweight subjects

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... n=60) and obese subjects (n=60) according to Asian criteria. Thyroid hormone levels were assessed by commercially available Enzyme linked immunosorbent assay (ELISA) kits. Statistical analysis was done by SPSS (version 13.0). It is concluded that although thyroid function was in clinically normal range in all the subjects but when comparison was done between the groups using one way ANOVA serum T 3 concentration was significantly low in obese and overweight subjects in comparison with normal weight subjects (p≤0.005). Serum T 4 concentration was significantly lower in overweight and obese subjects in comparison to normal weight (p≤0.005). Serum TSH concentration was significantly higher in obese in comparison with normal weight (p≤0.005) while it was non significantly higher in overweight subjects (p≥0.05).