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DNA glycosylases safeguard the genome by locating and excising chemically modified bases from DNA. AlkD is a recently discovered bacterial DNA glycosylase that removes positively charged methylpurines from DNA, and was predicted to adopt a protein fold distinct from other DNA repair proteins. The crystal structure of Bacillus cereus AlkD presented here shows that the protein is composed exclusively of helical HEAT-like repeats, which form a solenoid perfectly shaped to accommodate a DNA duplexdoi:10.1016/j.jmb.2008.05.078 pmid:18585735 pmcid:PMC3763988 fatcat:6yj7vgwkjnas5lxuvgsnq7f2uy