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Modulation of Neuroprotective Effect of Ischemic Post-Conditioning by Dichlorobenzamil a Na+/Ca2+ Exchanger Inhibitor in Mice
Biological and Pharmaceutical Bulletin
The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na ؉ ؉ /Ca 2؉ ؉ exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impairment of memory and motor coordination. Ischemic post-conditioning involving three episodes of 10 s carotid artery occlusion with intermittent reperfusion of 10 s proceedingdoi:10.1248/bpb.33.585 pmid:20410590 fatcat:vebrcmvvdvglpbcjyuu7pc5w2u