Modulation of Neuroprotective Effect of Ischemic Post-Conditioning by Dichlorobenzamil a Na+/Ca2+ Exchanger Inhibitor in Mice

Hardeep Kaur, Amteshwar Singh Jaggi, Nirmal Singh
2010 Biological and Pharmaceutical Bulletin  
The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na ؉ ؉ /Ca 2؉ ؉ exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impairment of memory and motor coordination. Ischemic post-conditioning involving three episodes of 10 s carotid artery occlusion with intermittent reperfusion of 10 s proceeding
more » ... nged ischemic insult of 12 min, produced a significant decrease in cerebral infarct size along with reversal of ischemia-reperfusion-induced impairment of memory and motor coordination. Ischemic post-conditioning-induced neuroprotective effects were significantly abolished by pretreatment with dichlorobenzamil (DBZ 0.5, 1 mg/kg, intraperitoneal) a Na ؉ ؉ /Ca 2؉ ؉ exchange inhibitor. It may be concluded that Na ؉ ؉ /Ca 2؉ ؉ exchanger possibly plays an important role in ischemic post-conditioning-induced neuroprotection.
doi:10.1248/bpb.33.585 pmid:20410590 fatcat:vebrcmvvdvglpbcjyuu7pc5w2u