Learn the importance of trend analysis • To understand epidemiological changes in health and delivery of healthcare. • To assess the implementation of new evidence into clinical practice. • Assess real world effectiveness of discoveries (interrupted time series design; difference in differences, regression discontinuity). Learn methods of performing trend analysis • Cochrane-Armitage test for trend. • Differences Logistic/linear regression analysis with time as an independent variable.

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... g changes in aspects of the study population over time with relation to the main dependent and independent variables • Adjustment/confounding. • Interaction of covariates with time and outcomes. Refining the research question • Addressing limitations in the data.