The Balz-Schiemann reaction of 4-aminopyridine afforded 4-fluoropyridine (1) in 20% yield, but the special care was required because 1 was unstable under the aqueous conditions. Both the detailed reaction conditions and the appearance of the reaction mixture are reported in detail. The detailed experimental procedure for the isolation of 1 is also presented. Some comments for 1 H NMR spectrum of 1 are given. 1 ) is an useful reagent especially for the cooperation of 4-pyridyl group through the

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... romatic nucleophilic substitution. [1] The compound 1 is commercially available but expensive, one may plan the synthesis of 4-Fluoropyridine (