High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis

David P Relling, Lucy B Esberg, Cindy X Fang, W Thomas Johnson, Eric J Murphy, Edward C Carlson, Jack T Saari, Jun Ren
2006 Journal of Hypertension  
Conclusions Collectively, our data show that high-fat dietinduced obesity resulted in impaired cardiomyocyte function, upregulated Foxo3a transcription factor and mitochondrial damage without overt lipotoxicity or apoptosis.
doi:10.1097/01.hjh.0000203846.34314.94 pmid:16467659 fatcat:iwisukhfczaifcbsshed34dtsy