劇症1型糖尿病4症例の比較検討
Four Cases of Fulminant Type 1 Diabetes Mellitus

Kenro Imaeda, Naotsuka Okayama, Yoshinobu Kamiya, Takashi Kato, Masaya Akao, Seiji Imai, Yoshiyuki Takeuchi, Kazuko Wakami, Kazuhiro Yamada, Yoshinari Hayashi, Makoto Itoh
2005 Journal of the Japan Diabetes Society  
We studied 4 cases of diagnosed or suspected fulminant type 1 diabetes mellitus based on clinical factors, i.e., age, gender, pregnancy, duration between onset of symptoms and diagnosis, HbA1c, autoimmune antibodies, and HLA. Of the 4, 3 were women and a man, and one woman was pregnant. Age ranged from 29 to 69. Cases 3 and 4 had upper bronchitis before hyperglycemic symptom onset. The duration was 2 to 5 days, and the shorter the duration, the lower the HbA1c. None had antibodies against
more » ... ic acid decarboxylase, ICA, or IAA, and only case 1 had ICSA. Three of the 4 had HLA DRB1 * 0405-DQB1 * 0401, as haplotype susceptible to type 1 diabetes in Japanese. Taken together, we suggest that fulminant type 1 diabetes mellitus may be related to a variety of factors, e.g., gender, pregnancy, virus infection and autoimmunity. We also emphasize the importance of the HLA DRB1 * 0405-DQB1 * 0401 haplotype in fulminant type 1 diabetes mellitus onset.
doi:10.11213/tonyobyo.48.a53 fatcat:x5iwvs2oafcuzaa7wbmggf5lxq