Susceptibility of radiation chimeras to Trypanosoma cruzi

T M Trischmann
1982 Infection and Immunity  
Reciprocal bone marrow transfers were performed with C3H/HeJ mice, which are susceptible to infection with the Brazil strain of Trypanosoma cruzi, and resistant Ft (C3H/HeJ x C57BL/6J) mice. Mice reconstituted after lethal irradiation with syngeneic bone marrow displayed the resistance phenotype of the strain used, but neither C3H mice reconstituted with Ft bone marrow cells nor Fl mice reconstituted with C3H bone marrow cells survived challenge. Resistance to T. cruzi appears to be dependent
more » ... on factors associated both with host background and with bone marrow-derived cells.
doi:10.1128/iai.36.2.844-846.1982 fatcat:ylphabyvdvfv3bta2yllixbx5i