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Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing
2021
International Journal of Molecular Sciences
The sodium-activated potassium channel Slack (KNa1.1, Slo2.2, or Kcnt1) is highly expressed in populations of sensory neurons, where it mediates the sodium-activated potassium current (IKNa) and modulates neuronal activity. Previous studies suggest that Slack is involved in the processing of neuropathic pain. However, mechanisms underlying the regulation of Slack activity in this context are poorly understood. Using whole-cell patch-clamp recordings we found that Slack-mediated IKNa in sensory
doi:10.3390/ijms22010405
pmid:33401689
fatcat:okqgp7ifs5czlk7b6f3fqewqv4