Academic and Nonacademic Laboratories Perform Equally on CIQC Immunohistochemistry Proficiency Testing

Zhongchuan Will Chen, Heather Neufeld, Maria A. Copete, John Garratt, C. Blake Gilks, Emina E. Torlakovic
2013 American Journal of Clinical Pathology  
A b s t r a c t Objectives: To test whether academic centers (ACs) are more successful than nonacademic centers (NACs) in immunohistochemistry (IHC) external quality assessment challenges in the Canadian Immunohistochemistry Quality Control (CIQC) program. Methods: Results of 9 CIQC challenges for breast cancer marker (BM) and various non-breast cancer marker (NBM) tests were examined. Success rates were compared between AC/NAC laboratories and those located in small or large cities.
more » ... was also correlated with annual IHC case volumes. Results: There was no statistically significant difference in performance in any of the comparisons. However, overall performance on BM was significantly better (P < .0001, t test) than on NBM tests regardless of AC/NAC nature or city size. The mean failure rate on NBM was approximately twice that of BM tests. Conclusion: Our results suggest that recent emphasis on breast hormone IHC quality assurance has led to improved test quality. Chen_2012110589.indd 55 6/5/13 11:41 AM 56
doi:10.1309/ajcphbl59mwbvyrd pmid:23765534 fatcat:3tfmmtu7qbbdfielxllqsp6ona