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The Effects of Deregulated Cyclin E Expression in Mitosis: A Role in Breast Tumorigenesis
purpose of this project is to study the effect of constitutive cyclin E expression on mitotic division and to ultimately identify the mechanism through which cyclin E leads to chromosome instability. Cyclin E functions in timing the GI/S phase transition and centrosome duplication, but when cyclin E expression is deregulated cells enter S phase and exit more slowly and exhibit a moderate level of chromosome Instability. We propose that cyclin E may be interfering with mitotic division leadingdoi:10.21236/ada443699 fatcat:n7agcuxwjvg35mc2ohlm2wnpji