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Conclusion: Lower levels of AIM2 promoter total methylation might increase the risk of T2DM. NLRP3, AIM2, and ASC promoter total methylation or some CpG methylation loss might increase the risk of T2DM vascular complications, which merits further study to support the robustness of these findings.doi:10.3389/fendo.2018.00709 fatcat:lanqtav6fzda7dzudypr3nawui