Phospholamban Regulates the Ca2+-ATPase through Intramembrane Interactions

Yoshihiro Kimura, Kazimierz Kurzydlowski, Michihiko Tada, David H. MacLennan
1996 Journal of Biological Chemistry  
28 -52 was reversed by PLN antibody or by Flag antibody, demonstrating that inhibition by these constructs is reversible and that the inhibitory constructs are properly oriented in the membrane. These results suggest that PLN modulates the apparent Ca 2؉ affinity of SERCA2a through intramembrane interactions, which are disrupted at long range and in concert with disruption of the well characterized cytoplasmic interactions.
doi:10.1074/jbc.271.36.21726 pmid:8702967 fatcat:oncz7xzvaja7zd2idovsvfecwq