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MmpL8MAB controls Mycobacterium abscessus virulence and production of a previously unknown glycolipid family
Proceedings of the National Academy of Sciences of the United States of America
Mycobacterium abscessus is a peculiar rapid-growing Mycobacterium (RGM) capable of surviving within eukaryotic cells thanks to an arsenal of virulence genes also found in slow-growing mycobacteria (SGM), such as Mycobacterium tuberculosis. A screen based on the intracellular survival in amoebae and macrophages (MΦ) of an M. abscessus transposon mutant library revealed the important role of MAB_0855, a yet uncharacterized Mycobacterial membrane protein Large (MmpL). Large-scale comparisons withdoi:10.1073/pnas.1812984115 fatcat:tgytxb34mrfxrpnw5pjluohkry