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Effects of Extract of Arrabidaea chica Verlot on an Experimental Model of Osteoarthritis
International Journal of Molecular Sciences
The aim of this study was to analyze the analgesic potential of Arrabidaea chica extract (EHA) as an alternative to osteoarthritis (OA) treatment. Thus, the extract was initially evaluated by the cyclooxygenase inhibition test. The analgesic effect of the extract, in vivo, was also verified in a model of OA induced by sodium monoiodoacetate (2 mg). EHA was administered to rats at doses of 50, 150, and 450 mg/kg between 3 and 25 days after OA induction. The animals were clinically evaluateddoi:10.3390/ijms20194717 fatcat:7kvj2fpyizcjrjapxt55qff4wm