Bone mineral density in long-term survivors of highly malignant osteosarcoma

G. Holzer, P. Krepler, M. A. Koschat, S. Grampp, M. Dominkus, R. Kotz
2003 Journal of Bone and Joint Surgery  
e studied the bone mineral density (BMD) of 48 long-term survivors of highly malignant osteosarcoma who had been treated according to the chemotherapy protocols of the German-Swiss-Austrian Co-operative Osteosarcoma Study Group which include high-dose methotrexate. The mean age of the patients was 31 ± 4.2 years and the mean follow-up 16 ± 2.2 years. The BMD of the lumbar spine and of the proximal femur of the non-operated side was measured by dualenergy x-ray absorptiometry. A questionnaire
more » ... given to determine life-style factors, medical history and medication. Ten patients were osteoporotic, 21 osteopenic and 17 normal according to the WHO definition. Eighteen patients suffered fractures after receiving chemotherapy and all had significantly lower levels of BMD for all the sites measured. J Bone Joint Surg [Br] 2003;85-B:231-7.
doi:10.1302/0301-620x.85b2.13257 pmid:12678358 fatcat:ap5dfbwbangb7jnazzo53q2leq