AKR Thymic Lymphomas Involving Mink Cell Focus-Inducing Murine Leukemia Viruses Have a Common Region of Provirus Integration

Fayth K. Yoshimura, Kathryn L. Levine
1983 Journal of Virology  
Newly acquired proviruses related to a mink cell focus-inducing murine leukemia virus were detected in low copy number in restriction endonucleasedigested DNAs from thymic lymphomas of AKR/J mice. These extra proviruses were not present in DNAs of either normal thymus or leukemic brain tissues. Extra tumor-specific DNA fragments generated by restriction endonucleases either were identical in size or fell into similar size classes, suggesting a common site(s) of provirus integration.
more » ... ration. Characterization of extra EcoRI DNA fragments for mink cell focus-inducing viral sequences revealed that all of them contained large terminal repeat sequences and that a significant number represented proviruses with deletions. 576 on May 9, 2020 by guest
doi:10.1128/jvi.45.2.576-584.1983 fatcat:q4wnl4nl35bgdfjwukubj3aula