While glycolysis is vitally essential metabolism for energy production in cells, its enhancement is frequently observed in cancers, known as the Warburg effect. Although the importance of the Warburg effect is clinically defined, it is still not clear how the Warburg effect is coupled to the other cancerous hallmark, e.g. immortalization. Glycolysis would be dysregulated in cancers, which is supported by recent findings on their transcriptional regulation. But among others, phosphoglycerate

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... se, PGAM, is an outlier, as the heavy posttranscriptional regulation is operating for it. Here we review about the posttranscriptional regulation of PGAM, especially its ubiquitination by Mdm2 as we reported recently. To cite this article: Takumi Mikawa, et al. Posttranscriptional regulation of glycolytic enzyme phosphoglycerate mutase. Sci