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We report angioedema as a rare presentation leading to a diagnosis of systemic lupus erythematosus (SLE). A diagnosis of angioedema was delayed in a patient presenting with limb and facial swelling until she developed acute upper airway compromise. After excluding allergic and hereditary angioedema, acquired angioedema (AAE) was suspected, possibly precipitated by respiratory tract infection. Associated clinical and laboratory features led to a diagnosis of SLE. Management proved challengingpmid:17364082 fatcat:fq7uninzrjdrzn6a2om47woyba