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The computational reconstruction of genome sequences from shotgun sequencing data has been greatly simplified by the advent of sequencing technologies that generate long reads. In the case of relatively small genomes (e.g., bacterial or viral), complete genome sequences can frequently be reconstructed computationally without the need for further experiments. However, large and complex genomes, such as those of most animals and plants, continue to pose significant challenges. In such genomes,doi:10.1371/journal.pcbi.1006994 pmid:31166948 pmcid:PMC6550390 fatcat:3cxdpvhs2faifj35iciodxnbt4