Effects of Sesamol on Experimental Cisplatin Nephrotoxicity Model

Mehmet Emin Dilek, Ali Gürel, Akif Doğantekin, Kazım Şahin, İbrahim Hanifi Özercan, Necip İlhan, Hüseyin Çeliker
2020 Kafkas Journal of Medical Sciences  
Aim: Cisplatin causes oxidative damage in the kidney. Sesamol is one of the water-soluble and antioxidant compounds of sesame oil. We investigated the effect of sesamol on experimental cisplatin nephrotoxicity and lipid peroxidation. Material and Method: Twenty-eight male Wistar rats were used in 4 groups (n=7): control, sesamol (8 mg/kg/day), cisplatin (7 mg/kg i.p., single dose), and cisplatin + sesamol. Specimens were evaluated with biochemical, molecular and histopathologic methods. SPSS
more » ... kage programme was used for statistical analyses. Results: Urea and creatinine levels were significantly higher in the cisplatin group compared to the control group and were significantly decreased in the cisplatin+sesamol group (p<0.05). Cisplatin-treated rats showed a significant increase in malondialdehyde (MDA) levels (p<0.05). Sesamol significantly decreased MDA (p<0.05). Nuclear factor kappa B (NF-κB) levels increased in the cisplatin group compared to the control group and decreased significantly in the cisplatin+sesamol group (p<0.001). Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels were decreased in the cisplatin group compared to the control group (p<0.001) and increased significantly in the cisplatin+sesamol group (p<0.01). Histopathological changes with cisplatin decreased with sesamol. Conclusion: We determined that sesamol decreases lipid peroxidation and NF-κB levels and shows antioxidant effect by increasing Nrf2 and HO-1 levels on cisplatin induced nephropathy.
doi:10.5505/kjms.2020.54227 fatcat:5in7tlee7fa3hkt3zoc5wyikse