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The activity of the renin-angiotensin-aldosterone system (RAAS) in type2 diabetes (T2D) has been characterized. However, the effects of high-fat high carbohydrate diet-induced prediabetes on the RAAS has not been elucidated. Hence, male Sprague Dawley rats were randomly assigned to a normal diet (NPD) group and (HFHC) group (n=6) for 20 weeks to allow for the induction of prediabetes. Blood glucose concentration, mean arterial pressure (MAP), kidney renin, angiotensinogen,doi:10.21203/rs.3.rs-120506/v1 fatcat:2pd5b42z3jhrlpwpidlea645ii