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Population pharmacokinetic modeling and pharmacodynamic assessment of cefozopran in pediatric patients
2009
The Japanese Journal of Antibiotics
The aims of this study were to develop a population pharmacokinetic model for cefozopran in pediatric patients, and to use this model to evaluate the pharmacodynamics of cefozopran regimens against common bacterial populations. Plasma drug concentration data (110 samples from 31 pediatric patients) were modeled using the NONMEM program. The mean estimate and interindividual variance of the model were used in a Monte Carlo simulation to estimate the probabilities of attaining the bactericidal
pmid:20055120
fatcat:5bfghmjmo5bevke5sehj6rlw3i