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Application of a RP-HPLC method for determination of chemical and physiological stability of two newly synthesized methoxy-benzoylhydrazone derivatives

B Nikolova-Mladenova, L Peikova, M Georgieva, Al Zlatkov
2017 Bulgarian Chemical Communications   unpublished

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The study investigates the stability of novel aroylhydrazones containing susceptible to hydrolysis hydrazone group at conditions close to physiological. Two methoxy-derived hydrazones (3-methoxysalicylaldehyde benzoylhydrazone-3M and 4-methoxysalicylaldehyde benzoylhydrazone-4M) were dissolved in different buffer solutions (pH 2.0, 7.4 and 9.0) at 37 °C and aliquot samples were drawn at definite time intervals. Stability of the compounds was determined using precise, selective and validated
more » ... PLC method. No changes in the structures were detected at pH= 7.4 and pH = 9.0, whereas an appearance of new peaks corresponding to the retention time of the supposed hydrolysis products was observed at pH 2.0. The results revealed chemical stability of the tested compounds at neutral and low alkali pH under physiological temperature and hydrolytic sensibility at strong acidic medium.
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B Nikolova-Mladenova, L Peikova, M Georgieva, Al Zlatkov. "Application of a RP-HPLC method for determination of chemical and physiological stability of two newly synthesized methoxy-benzoylhydrazone derivatives." Bulgarian Chemical Communications (2017)