Piperacillin is a semisynthetic ureidopenicillin having antibacterial action against Gram-positive and Gram-negative aerobic and anaerobic bacteria of both the Gram positive and Gram-negative types. Despite this, the clinical utility of piperacillin has been weakened in recent years as a result of an increase in the incidence of -lactamase generating bacteria that are resistant to the antibiotic. Our patient was of 50 year old, got admitted to the general medicine ward with complaints of

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... essness (4-5 times), loss of appetite, altered sensorium since 2 days, loose motions at a frequency of 6 to 7 times on the day prior to admission, productive cough since 3 days. On evaluation of lab data and existing medical history and presenting symptoms, the patient was diagnosed with Acute exacerbation of bronchial asthma associated with necrosis and hypertension. On Day 1 of admission, patient was started on Injection piperacillin+Tazobactum 4.5g-IV-TID, the patient reported appearance of rashes over the chest area continued for 5 days. Patient was prescribed with anti-rash and anti-itching medication for ADR management. It is critical to use a multidisciplinary approach when treating patients whose health has been harmed by a medicine, as well as to identify and stop using the offending prescription.