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Kinase impact assessment in the landscape of fusion genes that retain kinase domains: a pan-cancer study
2016
Briefings in Bioinformatics
Assessing the impact of kinase in gene fusion is essential for both identifying driver fusion genes (FGs) and developing molecular targeted therapies. Kinase domain retention is a crucial factor in kinase fusion genes (KFGs), but such a systematic investigation has not been done yet. To this end, we analyzed kinase domain retention (KDR) status in chimeric protein sequences of 914 KFGs covering 312 kinases across 13 major cancer types. Based on 171 kinase domain-retained KFGs including 101
doi:10.1093/bib/bbw127
pmid:28013235
pmcid:PMC5952959
fatcat:zs4vay6bdjfw3dw2oz652z7kii